反应详情

An aqueous solution of sodium hydroxide (9.2 g) was added to an ice-cooled, stirred solution of methyl 2-chloro-5-methylnicotinoate (35.28 g) in methanol at such a rate so that the temperature of the reaction mixture did not exceed 30° C. The mixture was then stirred at room temperature for 1.5 hours. Solvent was evaporated. The residue was diluted with water and acidified to pH 2 with concentrated hydrochloric acid. The precipitate was collected by filtration, washed with water and dried to yield the title compound as a pale yellow solid, 31.92 g, m.p. 180°-180.5° C.

1. temperaturecooled
2. customdid not exceed 30° C
3. customSolvent was evaporated
4. additionThe residue was diluted with water
5. filtrationThe precipitate was collected by filtration
6. washwashed with water
7. customdried