1-{4-[1-(2-Phenylethyl)-1H-imidazole-2-carbonyl]piperidin-1-yl}ethan-1-one → HCID 19371531, compound

Participants

Reaction Steps

A mixture (3.87 g) of 1-acetyl-4-[[1-(2-phenylethyl)-1H-imidazol-2yl]carbonyl]piperidine (D), (1-acetyl-4-pipendinylidene)[1-(2-phenylethyl)-1H-imidazol-2-yl]methyl 1 -acetyl-4-piperidine carboxylate (H), and 6 N hydrochloric acid (100 ml) was refluxed for 20 hrs. The cooled reaction mixture was concentrated, and the residue was diluted with water. The resulting mixture was sequentially washed with ether and ethyl acetate. The acidic aqueous layer was basified with sodium hydroxide solution and was extracted with dichloromethane. The combined extracts were washed with water, dried, filtered, and concentrated to give [1-(2-phenyethyl)-1H-imidazol-2-yl](4-piperidinyl) methanone (K, 0.91 g), m.p. 230°-232° C. from dichloromethane-hexanes. ##STR31##

Provenance & Evidence