Acetyl chloride → HCID 20087668, compound

Participants

Reaction Conditions

Reaction Steps

1.0 g (10 mmol) of triethylamine and then 0.8 g (10 mmol) of acetyl chloride are added dropwise at 0° C. to 3.2 g (10 mmol) of 5-ethoxycarbonyl-4-hydroxy-6-methyl-3-(2,4,6-trimethylphenyl)pyrone in ml of ethyl acetate. The mixture is stirred for 20 hours at 20° C. and filtered, the organic phase is washed with semi-concentrated sodium chloride solution and dried over sodium sulphate and the solvent is evaporated in vacuo. The residue is chromatographed on silica gel (35-70 μm) using toluene/acetone (40:1 parts by volume). 2.9 g of 4-acetoxy-5-ethoxycarbonyl-6-methyl-3-(2,4,6-trimethylphenyl)pyrone are obtained (yield: 81% of theory). M.p.=107° to 109° C.

Provenance & Evidence