Triethylamine → HCID 20087667, compound

Participants

Reaction Conditions

Reaction Steps

2.0 g (20 mmol) of triethylamine and subsequently 2.2 g (20 mmol) of ethyl chloroformate in 20 ml of ethyl acetate are added dropwise at 0° C. to 5.7 g (20 mmol) of 4-hydroxy-6-tert.-butyl-3-(2,4,6-trimethylphenyl)pyrone in 50 ml of ethyl acetate. The mixture is stirred for 20 hours at 20° C. and filtered, the organic phase is washed with semi-concentrated sodium chloride solution and dried over sodium sulphate, and the solvent is evaporated in vacuo. The residue is chromatographed on silica gel (35-70 μm) using toluene/acetone (20:1 parts by volume). 6.0 g of 4-ethoxycarbonyloxy-6-tert.-butyl-3-(2,4,6-trimethylphenyl)pyrone are obtained (yield: 84% of theory). M.p.=92°-94° C.

Provenance & Evidence