1-Chloro-4-(chloromethyl)benzene → HCID 25142816, compound

Participants

Reaction Conditions

Reaction Steps

Add a solution of cis-5,6a,7,8,9,9a-hexahydro-5-methylcyclopenta[4,5]imidazo[2,1-b]purin-4-one (0.5 g=2.2 mmol)in DMF drop-wise to a slurry of 60% NaH (0.1 g=2.4 mmol) in DMF at 30° C. When gas evolution ceases, add 4-chlorobenzyl chloride (0.5 g=2.4 mmol) in 2 ml DMF. Heat at 50° C. two hours. Remove DMF and partition between EtOAc and water. Dry, solvent strip, and recrystallize from CH3CN to give the title compound, a white solid. CI MS: M+ =356.

Provenance & Evidence