化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethyl-3-[(trimethylacetoxy)methyl]-cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,5-dimethyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one | HCID 10776762 | — |
| 反応物 | 4-Chloro-2,2-dimethylbutanoate | HCID 21753047 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethyl-3-[(trimethylacetoxy)methyl]-cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one | HCID 18659403 | — |
反応手順
Treat 5,6a(R),7,8,9,9a(S)-hexahydro-2,5-dimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one from Example 19a (0.28 g, 1.1 mmol) in DMF with (4 ml) with potassium carbonate (0.24 g) and chloromethylpivalate (0.2 ml, 1.4 mmol) at 35° C. for 6 hr. Cool and filter the reaction mixture. Partition the filtrate with brine and ethyl acetate: THF 1:1. Dry and concentrate the organic layer to give the title compound as a powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05393755 |
| 出典データセット | uspto-grants-1995_02 |
| ORD ID | ord-94655324a3ca4ebc93fe2e84463a251d |
| 出典メモ | uspto-grants-1995_02 |