HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 6-Amino-3-methyl-5-(phenylmethyleneamino)pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-Amino-3-methyl-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 3247720 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Amino-3-methyl-5-(phenylmethyleneamino)pyrimidine-2,4-dione | HCID 12635933 | — |
Reaction Steps
6-amino-3-methyl-5-nitrosopyrimidine-2,4-dione (37.5 g=0.22 mol) with 10% palladium on carbon (Pd/C) (1.9 g) and 25% NaOH (25 ml) in 0.75L water. Hydrogenate at 50 psi for 3 hr, filter through Celite, and dilute to 1.5L with water. Adjust to pH 4.5 with HOAc and add benzaldehyde (35 g=0.34 mol). Add 0.5 kg ice, collect the solid, wash with water, then acetonitrile, and dry to give the title compound as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05393755 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-f928af98490e40b0831fcfb9f019df66 |
| Source note | uspto-grants-1995_02 |