HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 275333Generated: October 31, 2026
Ethyl orthoformate → 7-benzyl-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
https://huagongshe.com/reaction/275333
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 6-Amino-3-methyl-5-(phenylmethylamino)pyrimidine-2,4-dione | HCID 12500504 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-benzyl-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione | HCID 11118667 | — |
Reaction Steps
To 6-amino-3-methyl-5-(phenylmethylamino)pyrimidine-2,4-dione (24.6 g=0.1 mol) in DMF (125 ml) at 60° C. add triethyl orthoformate (75 ml=0.45 mol). Heat to 110° C. for 5 hr, cool in ice, filter, and wash with methanol, then ether, to obtain the title compound, m.p. 268°-71° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05393755 |
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| Source dataset | uspto-grants-1995_02 |
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| ORD ID | ord-a1f1974372d84433be00f25b58dcdfbe |
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| Source note | uspto-grants-1995_02 |
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