HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 7-benzyl-2-chloro-1-methyl-1,7-dihydro-6H-purin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 7-benzyl-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione | HCID 11118667 | — |
| Product | 7-benzyl-2-chloro-1-methyl-1,7-dihydro-6H-purin-6-one | HCID 3653021 | — |
Reaction Steps
Heat 1-methyl-7-(phenylmethyl)purine-2,6-dione (8.0 g=31 mmol)in POCl3 (80 ml) at reflux 7 hr. Concentrate in vacuo, partition EtOAc-ice water, wash with water, dry and concentrate. Chromatograph on silica with 98:2 CH2Cl2 /MeOH to obtain the title compound as a foam, FAB MS: M+1=275.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05393755 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-1074914a4cf04515a9585617472a151e |
| Source note | uspto-grants-1995_02 |