HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(trans-2-Hydroxycyclopentylamino)-1-methyl-7-(phenylmethyl)purin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7-benzyl-2-chloro-1-methyl-1,7-dihydro-6H-purin-6-one | HCID 3653021 | — |
| Reactant | rac-(1R,2R)-2-aminocyclopentan-1-ol | HCID 10464306 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(trans-2-Hydroxycyclopentylamino)-1-methyl-7-(phenylmethyl)purin-6-one | HCID 10593174 | — |
Reaction Steps
Heat at reflux for 2 days a mixture of 2-chloro-1-methyl-7-(phenylmethyl)purin-6-one (3.14 g=11.4 mmol), triethylamine (1.7 g=16.8 mmol), and (±)-trans-2-aminocyclopentanol (4.04 g=39.9 mmol) in CH3CN (150 ml). Collect the precipitate, wash with water, and dry to give the title compound, a solid, FAB MS: M+1=340.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05393755 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-bfe3f2de2c344b3c935a8b5c8c02b846 |
| Source note | uspto-grants-1995_02 |