Acetic Acid → HCID 14969713, compound

HRID 275339Notes

Reaction equation

HRID 275339 reaction equation
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:4](=[O:16])[CH:3]=1.[N:17]([O-])=[O:18].[Na+].C(O)(=O)C>O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:4](=[O:16])[C:3]=1[N:17]=[O:18]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14969707HCID 14969707, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 14969713HCID 14969713, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Slurry 6-amino-3-(phenylmethyl)-pyrimidine-2,4-dione (1.1 g=5 mmol) in 50 ml water. Add NaNO2 (0.63 g=9.1 mmol), warm to 75° C. and add acetic acid (2.6 ml=45 mmol) in 30 ml water over two hours. Collect the product, water wash and dry over P2O5 to give title compound as an orange solid. EI MS: M+=246.

Workup

  1. customCollect the product, water
  2. washwash
  3. dry with materialdry over P2O5

Sources & evidence

ORD record
ord-5e56a1dc7c8e4248a42a96c79afba5dd
Source dataset
uspto-grants-1995_02
Patent number
US05393755

Reaction notes

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