(1R,2R)-2-Aminocyclohexanol → HCID 54066511, compound

HRID 275342Notes

Reaction equation

HRID 275342 reaction equation
Cl[C:2]1[N:3]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:4](=[O:18])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1.[NH2:26][C@@H:27]1[CH2:32][CH2:31][CH2:30][CH2:29][C@H:28]1[OH:33]>>[OH:33][C@@H:28]1[CH2:29][CH2:30][CH2:31][CH2:32][C@H:27]1[NH:26][C:2]1[N:3]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:4](=[O:18])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 200878862-Chloro-1,7-bis(phenylmethyl)purin-6-one

Product 1

HCID 54066511HCID 54066511, compound

Procedure

Treat 2-chloro-1,7-bis(phenylmethyl)purin-6-one with trans-2-aminocyclohexanol as described in Preparative Example 5 to give the title compound, a tan foam. FAB MS: M+1=430.

Sources & evidence

ORD record
ord-b4ad3b78def64d0ba0faa0de90809fc7
Source dataset
uspto-grants-1995_02
Patent number
US05393755

Reaction notes

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