Hydrochloric Acid → HCID 20087845, compound

Participants

Reaction Steps

To a solution of 8a-nitrodecahydronapthalen-1-one [P. Dampawan and W. W. Zajac Jr. Synthesis, 545, 1983] (1.2 g, 6.1 mmol) in MeOH (10 ml) at 0° C., add sodium borohydride (0.09 g) and warm to RT. After 0.5 hr, add ether and 1N HCl. Dry and concentrate the organic layer. Dissolve the residue in EtOH (50 ml) and add this to Raney Nickel (1.2 g, wet weight) and place under 60 psi of H2 at 55° C. After 24 hr., filter though celite and concentrate to dryness. Dissolve the resultant oil in Et2O add dry HCl in MeOH and collect the title compound as a colorless precipitate EI MS: M+=169.

Provenance & Evidence