HCID 10471407, compound → HCID 10381888, compound

Participants

Reaction Steps

6-Chloro-3-(4-fluorophenyl)-1-(4-pyridyl)-lH-indole 2e (1.8 g) was dissolved in acetic acid (100 ml) and PtO2 (0.2 g) was added. After hydrogenation for 30 h at 3 ato the catalyst was filtered off, the acetic acid was evaporated in vacuo and water (50 ml) was added. The acidic solution was made alkaline (pH>9) with concentrated sodium hydroxide and extracted with ethyl acetate (2×50 ml). The combined organic phases were successively washed with diluted sodium hydroxide (50 ml), washed with brine, and dried (Na2SO4). Evaporation of the solvent gave 1.5 g of the title compound as an oil.

Provenance & Evidence