Sodium borohydride → HCID 10048445, compound

Participants

Reaction Steps

4-[2,5-Dimethyl-3-(4-fluorophenyl)-1H-indol-1-yl]-1-[2-(imidazolidin-2-on-1-yl)ethyl]-pyridinium iodide 5a (6.3 g) was suspended in ethanol (100 ml) and sodium borohydride (2.1 g) was added in three portions during 3.5 h. Then the solvent was evaporated in vacuo and water (100 ml) was added. The mixture obtained was extracted with dichloromethane (2×50 ml). The combined organic phases were washed with brine (100 ml) and dried (MgSO4). Evaporation of the solvent gave the title compound as an oil, which was purified by column chromatography on silica gel (eluted with ethyl acetate/ethanol 8:1 containing 4% triethylamine). Yield: 2.5 g, mp 151°-153° C.

Provenance & Evidence