HCID 10254306, compound → HCID 9845791, compound

HRID 275357Notes

Reaction equation

HRID 275357 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17](F)(F)F)[CH:15]=3)[N:10]([CH:21]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][N:29]4[CH2:33][CH2:32][NH:31][C:30]4=[O:34])[CH2:23][CH2:22]3)[CH:9]=2)=[CH:4][CH:3]=1.N1(CCN2CCC(N3C4C(=CC=CC=4)C(C4C=CC=CC=4)=C3C)CC2)CCN[C:36]1=O>>[CH3:36][C:9]1[N:10]([CH:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][N:29]3[CH2:33][CH2:32][NH:31][C:30]3=[O:34])[CH2:23][CH2:22]2)[C:11]2[C:16]([C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2

Participants

3

Reactant 2

HCID 10254306HCID 10254306, compoundHCID 21733291HCID 21733291, compound

Product 1

HCID 9845791HCID 9845791, compound

Procedure

In a corresponding manner the following indole derivatives were prepared: 3-(4-Fluorophenyl)-1-[1-[2-(imidazolidin-2-on-1-yl)ethyl]-4-piperidyl]-5-trifluoromethyl-1H-indole 7b, mp 182°-186° C 1-[1-[2-(Imidazolidin-2-on-1-yl)ethyl]-4-piperidyl]-2-methyl-3-phenyl-1H-indole 7c, mp 179°-183° C.

Sources & evidence

ORD record
ord-a08cd817e38042dfaa3e173caec07754
Source dataset
uspto-grants-1995_02
Patent number
US05393761

Reaction notes

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