Methyl chloroformate → HCID 20087990, compound

Participants

Reaction Steps

A mixture of 3-(4-fluorophenyl)-5-methyl-l-(4-piperidyl)-1H-indole 3d (6.0 g). K2CO3 (3.0 g) and dichloromethane (50 ml) was cooled to 0°-5° C. and a solution of methyl chloroformate (2.2 g)in dichloromethane (50 ml) was added during 0.5 h. After reaction for further 2 h at room temperature the reaction mixture was washed with water (2×100 ml) and dried (MgSO4). Evaporation of the solvents in vacuo afforded the title compound, which was used without further purification. Yield: 6.7 g, (oil).

Provenance & Evidence