Potassium Iodide → HCID 86747157, compound

Participants

Reaction Steps

A mixture of 7.6 g of known 1-(2-chloroethyl)-1-ethyl-3,4-dihydro-6-methoxy-1H-2-benzopyran, 9 g of 1-[4,4-bis(4-fluorophenyl)butyl]piperazine, 0.4 g of potassium iodide, and 5 g of potassium carbonate in 100 ml of dimethylformamide was refluxed for 6 h. After hydrolysis the mixture was extracted with dimethyl ether, and the ethereal phase was washed, dried, and evaporated. The base was precipitated and the dimaleate salt was prepared in ethanol and recrystallized from ethanol-water (3:1) to give 13.8 g of 1-[2-(1-ethyl-3,4-dihydro-6-methoxy-1H-2-benzopyran-1-yl)ethyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine (Z)-2-butenedioate (1:2) salt. mp 184° C.

Provenance & Evidence