Water → HCID 86747158, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8 g of 1-[(3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1-yl)methyl]-4-(phenylmethyl)piperazine, 9.1 g of 1,1-bis(4-fluorophenyl)-4-chlorobutane and 5.6 g of potassium carbonate in 75 ml of dimethylformamide was heated at 90° C. for 2 h. After addition of water the mixture was extracted with diethyl ether, the ether phase was washed, dried and evaporated and the dimaleate prepared as previously described to obtain 5.3 g (36.5%) of 1-[4,4-bis(-4-fluorophenyl)butyl]-4-[(3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1-yl)methyl]piperazine (Z)-2-butenedioate (1:2) salt. mp 205° C.

Provenance & Evidence