Water → HCID 86747158, compound

Participants

Reaction Steps

14.2 g of (+)-1-[(3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1-yl)methyl]-piperazine were reacted with 13.6 g of 1,1-bis(4-fluorophenyl)-4-chlorobutane and 8 g of potassium carbonate in 100 ml of dimethyl formamide for 2 h. Water was added to the mixture and after work up, the dimaleate was prepared as previously described to obtain 11.4 g of (+)-1-[4,4-bis(4-fluorophenyl)butyl]-4-[(3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1yl)methyl]piperazine (Z)-2-butenedioate (1:2) salt. mp 200° C. The free base has an optical rotation of [α]D20 =+38.5° (c=1, methanol).

Provenance & Evidence