HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → n-(5-Amino-2-methoxyphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Methoxy-5-nitroaniline | HCID 7447 | — |
| Reactant | AcOH AcOAc | HCID 21895370 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | n-(5-Amino-2-methoxyphenyl)acetamide | HCID 267867 | — |
Reaction Steps
2-Methoxy-5-nitroaniline was purchased and acetylated using HOAc/Ac2O in H2O/THF according to known procedures to make 2-methoxy-5-nitroacetanilide. This was reduced using catalytic hydrogenation (PtO2, H2, EtOH) to afford 3-acetamido-4-methoxyaniline which was reacted as described in Examples 1 and 2 to yield the desired glutarimide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05393735 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-a425c07c7b5d406baa6be5ac9f3e315a |
| Source note | uspto-grants-1995_02 |