Acetic Acid → HCID 20086526, compound

HRID 275458Notes

Reaction equation

HRID 275458 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]([C:12]2([CH3:32])[CH2:17][CH2:16][C:15]3[C:18]([CH3:31])=[C:19]([O:24][CH2:25][C:26]([O:28]CC)=[O:27])[C:20]([CH3:23])=[C:21]([CH3:22])[C:14]=3[O:13]2)=[S:11])[CH:3]=1.[OH-].[Na+].C(O)(=O)C>C(O)C.O>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]([C:12]2([CH3:32])[CH2:17][CH2:16][C:15]3[C:18]([CH3:31])=[C:19]([O:24][CH2:25][C:26]([OH:28])=[O:27])[C:20]([CH3:23])=[C:21]([CH3:22])[C:14]=3[O:13]2)=[S:11])[CH:3]=1

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 20086574HCID 20086574, compound

Product 1

HCID 20086526HCID 20086526, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

1.77 grams (4 mmol) of the compound of Example 67 are dissolved in 40 cm3 of ethanol. 4 cm3 of 2N sodium hydroxide are added dropwise. The mixture is stirred for 2 hours, then the reaction mixture is diluted with 60 cm3 of water and acidified with acetic acid. The mixture is filtered, washed with water and then dried to obtain the title product.

Workup

  1. filtrationThe mixture is filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-d98f39d3f8ae4fa0b17e3728ef2d4618
Source dataset
uspto-grants-1995_02
Patent number
US05393775

Reaction notes

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