Ammonium Chloride → HCID 20088788, compound

Participants

Reaction Steps

To a solution of 0.814 g (0.0025 mole) of 2,6-bis (1,1-dimethylethyl) -4- [1- (hydroxyamino)ethyl]phenol acetate (Example 2) in THF (10 mL) is added 0.868 g (0.0075 mole) of 85% trimethylsilyl isocyanate. The reaction mixture is heated under reflux for 45 minutes and allowed to stand at room temperature for 16 hours. The mixture is poured into saturated NH4Cl, concentrated to remove THF, extracted with EtOAc and dried over Na2SO4. The extracts are evaporated to dryness and the residue is recrystallized from Et2O-n-hexane to give white crystals, 0.46 g (60%), m.p. 162°-163.5° C.

Provenance & Evidence