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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 27560Generated: October 30, 2026

Thionyl Chloride → 5-Benzyl-4-chloromethyloxazole

https://huagongshe.com/reaction/27560

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
ReactantHCID 15555621HCID 15555621—
Reactant5-Benzyl-4-hydroxymethyloxazoleHCID 20557606—
Product5-Benzyl-4-chloromethyloxazoleHCID 20557836—

Reaction Steps

5-Benzyl-4-oxazolecarboxylic acid is converted to 5-benzyl-4-hydroxymethyloxazole by the procedure of Example 135. Treating this hydroxymethyl compound with thionyl chloride gives 5-benzyl-4-chloromethyloxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04221802
Source datasetuspto-grants-1980_09
ORD IDord-425d2671bc1640a6b5421cd4258c4745
Source noteuspto-grants-1980_09