HCID 54181919, compound → HCID 53739668, compound

Participants

Reaction Steps

A solution of 610mg (1.59mmol) (S)-α-[[[1-methyl-1-(morpholinocarbonyl)ethyl]sulfonyl]methyl]hydrocinnamic acid in 20 ml of methanol was hydrogenated in the presence of 60 mg of rhodium on aluminium oxide at 500 for 4 hours at a pressure of 106Pa of hydrogen. Subsequently, the catalyst was filtered off and rinsed with methanol. The methanolic solution was evaporated under reduced pressure, whereby 580 mg of (S)-α-[[[1-methyl-1-(morpholinocarbonyl)ethyl]sulfonyl]methyl]cyclohexanepropionic acid, MS: 346 (M-C3H7)+ were obtained as a colourless crystalline solid.

Provenance & Evidence