2,6-Dimethylmorpholine → benzyl (RS)-alpha-[[[1-[(cis-2,6-dimethylmorpholino)carbonyl]-1-methylethyl]sulfonyl]methyl]hydrocinnamate

Participants

Reaction Steps

In an analogous manner to that described in Example 2, paragraphs (c) and (d), by the reaction of (RS)-2-[[2-[(benzyloxy)carbonyl]-3-phenylpropyl]sulfonyl]-2-methylpropionyl chloride with 2,6-dimethylmorpholine in pyridine followed by chromatographic separation of the resulting diastereomers there was obtained benzyl (RS)-α-[[[1-[(cis-2,6-dimethylmorpholino)carbonyl]-1-methylethyl]sulfonyl]methyl]hydrocinnamate, MS: 501 (M)+, as a colourless oil.

Provenance & Evidence