反应详情

温度

70 °C

A mixture of 2 (1 mmol), 3-aminoheptane (1.2 mmol), Pd2(DBA)3 (0.02 mol, 4 mol % Pd, 18 mg), BINP (0.04 mmol, 25 mg), NaOtBu (1.4 mmol, 134 mg), and toluene (0.11 M with 3-bromopyridine, 9 ml) is heated to 70° C. under nitrogen until 2 is consumed. The reaction is then cooled to room temperature, and taken up in 10 ml diethyl ether, washed 3 times with 10 ml saturated brine, dried over MgSO4, and condensed in vacuo . The crude product is purified by flash chromatography to afford 3.

1. customis consumed
2. temperatureThe reaction is then cooled to room temperature
3. washwashed 3 times with 10 ml saturated brine
4. dry with materialdried over MgSO4, and condensed in vacuo
5. customThe crude product is purified by flash chromatography
6. customto afford 3