Phosphorus oxychloride → HCID 22267327, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-methyl-3-carboxy-4-hydroxy-8-(2′,4′-dichlorophenyl)-1,7-naphthyridine (0.41 g, 1.2 mmole) in diphenyl ether (0.4 ml) is stirred and heated to 230° C. for 1.5 h. The solution is allowed to cool to rt. and POCl3 (0.8 ml) is added. This mixture is heated to 100° C. for 2 h, then allowed to cool to r.t., and poured into 5% NaHCO3. This is extracted with EtOAc, the organic phase washed with brine, dried and concentrated. The product is purified by flash chromatography on silica gel to give the title compound D7.

Provenance & Evidence