2-Indancarboxylic Acid → 7-Chloro-3-[1-[(indan-2-yl)carbonyl]-1,2,3,6-tetrahydopyrid-4-yl]-1H-indole

HRID 275706Notes

Reaction equation

HRID 275706 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[C:10]([OH:12])=O.[Cl:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:22]=1[NH:21][CH:20]=[C:19]2[C:23]1[CH2:24][CH2:25][NH:26][CH2:27][CH:28]=1>>[Cl:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:22]=1[NH:21][CH:20]=[C:19]2[C:23]1[CH2:24][CH2:25][N:26]([C:10]([CH:2]2[CH2:1][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3]2)=[O:12])[CH2:27][CH:28]=1

Participants

3

Reactant 2

HCID 5757772-Indancarboxylic AcidHCID 185458497-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Product 1

HCID 700929927-Chloro-3-[1-[(indan-2-yl)carbonyl]-1,2,3,6-tetrahydopyrid-4-yl]-1H-indole

Procedure

Prepared from 9a and 7-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole.

Sources & evidence

ORD record
ord-41a92948adad4e869d141cb4288c12c7
Source dataset
uspto-grants-2002_03
Patent number
US06352988B2

Reaction notes

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