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Diethyl Malonate → 4-(6-Acetylaminoindan-1-yl)butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Malonate | HCID 7761 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Indane | HCID 10326 | — |
| 反応物 | 6-Nitro-2,3-dihydro-1H-indene-1-carboxylic acid | HCID 12318488 | — |
| 生成物 | 4-(6-Acetylaminoindan-1-yl)butanoic acid | HCID 18545843 | — |
| 生成物 | 2-(6-Acetylaminoindan-1-yl)acetic acid | HCID 18545899 | — |
| 生成物 | 3-(6-Acetylaminoindan-1-yl)propanoic acid | HCID 18545930 | — |
反応手順
2-(6-acetylaminoindan-1-yl)acetic acid, 3-(6-acetylaminoindan-1-yl)propanoic acid and 4-(6-acetylaminoindan-1-yl)butanoic acid were prepared from 6-nitro-1-indanecarboxylic acid by classical chain elongations by using KCN or diethyl malonate. The methodology is described for an analogous indane serie by R. Gruber et al. Tetrahedron 1974, 30, 3605-10. Alane was used for the reduction of the intermediate carboxylic acids.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06352988B2 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-1d8dff618eea4c10821b1ba2ac21b4d3 |
| 出典メモ | uspto-grants-2002_03 |