反应详情

A mixture of 4-(piperazin-1-yl)-1H-indole (1.5 g), 2-(2-iodoethyl)indane (2.0 g), K2CO3, methyl isobutyl ketone (150 ml), and N-methylpyrrolidone (10 ml) was boiled under reflux for 3 h. The mixture was allowed to cool to room temperature, filtered, and concentrated in vacuo. The residue was purified on silica gel eluted with ethyl acetate-heptane (1:2) to give a crystalline compound, which was recrystallized (ethyl acetate) to give the title compound (1.2 g, 47%).

1. temperatureunder reflux for 3 h
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. customThe residue was purified on silica gel
5. washeluted with ethyl acetate-heptane (1:2)
6. customto give a crystalline compound, which
7. customwas recrystallized (ethyl acetate)