HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Methylthiophenylboric acid → 6,7-Dimethoxy-2-methylamino-4-[5-(4-methylthiophenyl)-3-pyridyl]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Methylthiophenylboric acid | HCID 21939890 | — |
| Reactant | HCID 22663121 | HCID 22663121 | — |
| Product | 6,7-Dimethoxy-2-methylamino-4-[5-(4-methylthiophenyl)-3-pyridyl]quinazoline | HCID 22950994 | 105.2% |
Reaction Steps
Starting from 375 mg of 4-(5-bromo-3pyridyl)-6,7-dimethoxy-2-methylaminoquinazoline obtained in Example 76 and 225 mg of 4-methylthiophenylboric acid, 440 mg of the title compound was obtained as pale yellow crystals in the same manner as in Example 48. m.p.; 170-172° C. MASS 419 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06352989B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-812216dd3a164c6bbc37e268d4fde915 |
| Source note | uspto-grants-2002_03 |