反应详情

A solution of 2-(1-hydroxyethyl)-4-methoxybenzimidazole (2.18 g) in acetic acid (8.5 ml) was heated at 100° C. and treated with a solution of chromium trioxide (0.85 g) in water (3 ml). After 10 minutes the reaction was poured into water (110 ml), the precipitate was removed by filtration through a plug of Celite and the product extracted with dichloromethane (3×100 ml). The combined organic layers were dried over magnesium sulphate, filtered, and evaporated in vacuo and to yield the desired product as a light-brown solid (1.4 g).

1. customthe precipitate was removed by filtration through a plug of Celite
2. extractionthe product extracted with dichloromethane (3×100 ml)
3. dry with materialThe combined organic layers were dried over magnesium sulphate
4. filtrationfiltered
5. customevaporated in vacuo