N-bromobutanimide → HCID 178488288, compound

Participants

Reaction Steps

A solution of 7-methoxy-2-trifluoromethylbenzimidazole (50 g) in chloroform (100 ml) was cooled to 0° C., and N-bromosuccinimide (4.5 g) added. The mixture was stirred for 2 h. It was then washed with 5% aqueous sodium metabisulphite (50 ml), dried over magnesium sulphate, evaporated in vacuo and purified by flash chromatography eluting with 25% ethyl acetate in hexane to yield the title compound as a white solid (1.0 g).

Provenance & Evidence