HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 9-(2-Hydroxyethyl)-1H-purin-6(9H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(6-Chloro-9h-purin-9-yl)ethanol | HCID 234010 | — |
| Solvent | Water | HCID 962 | — |
| Product | 9-(2-Hydroxyethyl)-1H-purin-6(9H)-one | HCID 135408581 | — |
Reaction Steps
6-Chloro-9-hydroxyethyl purine, III (4 g), was added slowly to warm N NaOH (30 ml) and refluxed for 2 hr. The reaction is cooled in ice and neutralized with glacial acetic acid. After filtration, portions of unreacted III are removed. The product is recrystallized from methanol and washed with acetone. Colorless crystals. Yield, 1 g. (28%) mp. 274°; uv (H2O, pH 5.5), λmax 250 nm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221910 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-5dfd6319591e4abe8a86c156ccd56b0e |
| Source note | uspto-grants-1980_09 |