反应详情

In methanol (12 ml) was dissolved 2-amino-3′-tert-butoxycarbonylaminomethyl-5-isobutyloxy-benzophenone (0.38 g). To the solution was added, while stirring at room temperature, sodium borohydride (50 mg). The reaction mixture was concentrated, to which was added water, followed by extraction with ethyl acetate (50 ml). The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to leave 2-amino-α-(3-tert-butoxycarbonylaminomethylphenyl)-5-isobutyloxy-benzyl alcohol as a yellow oily product (0.36 g).

1. additionTo the solution was added
2. concentrationThe reaction mixture was concentrated, to which
3. additionwas added water
4. extractionfollowed by extraction with ethyl acetate (50 ml)
5. washThe organic layer was washed with water
6. dry with materialdried over anhydrous sodium sulfate
7. distillationThe solvent was distilled off