Tetrahydrofuran → HCID 18315367, compound

Participants

Reaction Steps

A tetrahydrofuran (30 ml) solution of N-methyl-N-methyloxy-2-amino-5-chlorobenzamide (3.22 g) and N-trityl-3-bromobenzylamine (4.28 g) was cooled to −78° C. To the solution was gradually added dropwise a hexane solution of n-butyl lithium (1.6 mol/L) (31 ml). To the mixture were then added water (70 ml) and acetic acid ethyl ester (100 ml). The organic layer was washed with water and dried over anhydrous MgSO4. The solvent was distilled off, and the residual yellow oily compound was purified by a silica gel column chromatography to give 2-amino-3′-tritylaminomethyl-5-chlorobenzophenone (2.2 g) as a yellow oily product.

Provenance & Evidence