Water → HCID 53892090, compound

Participants

Reaction Conditions

Reaction Steps

4-(41-Hydroxyphenyl)benzoic acid (2.0 g) was dissolved in N,N-dimethylformamide (30 ml). To the solution were added benzyl bromide (3.99 g) and potassium carbonate (3.86 g). The mixture was stirred for 3 hours at 80° C. The reactiontmixture was poured into water (100 ml), which was subjected to extraction with ethyl acetate (150 ml). The organic layer was washed with 5% potassium hydrogensulfate, which was then washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to leave 4-(4′-benzyloxyphenyl)-benzoic acid benzyl ester as a scale-like crystalline product (3.4 g). m.p.: 138-140° C.

Provenance & Evidence