反应详情

6-Chloro-9-hydroxyethyl purine, III (4 g), was added slowly to warm N NaOH (30 ml) and refluxed for 2 hr. The reaction is cooled in ice and neutralized with glacial acetic acid. After filtration, portions of ureacted III are removed. The product is recrystallized from methanol and washed with acetone. Colorless crystals. Yield, 1 g. (28%); mp. 274°; uv (H2O, pH 5.5); λmax 250 nm.

1. temperaturerefluxed for 2 hr
2. filtrationAfter filtration, portions of ureacted III
3. customare removed
4. customThe product is recrystallized from methanol
5. washwashed with acetone
6. customYield