反应详情

To a solution of 3-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-hydroxy-benzonitrile hydrochloride (0.20 g, 0.75 mmol) in 3 mL of pyridine at 0° C. is added 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The solution is allowed to warm to ambient temperatures and is stirred for 6 h. After this time, the solution is concentrated. The residue is dissolved in CH2 Cl2. The organic solution is washed with 1N HCl and saturated NaCl. The crude product is triturated with Et2O to give the title compound (0.22 g, 0.44 mmol) as a white solid.

1. temperatureto warm to ambient temperatures
2. concentrationAfter this time, the solution is concentrated
3. dissolutionThe residue is dissolved in CH2 Cl2
4. washThe organic solution is washed with 1N HCl and saturated NaCl
5. customThe crude product is triturated with Et2O