Phenethylamine → 5,6-Dimethyl-2-phenylethylamino4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride

HRID 275911Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 275911
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.[Cl:17][C:18]1[N:23]=[C:22]([N:24]2[CH2:33][CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:25]2)[C:21]([CH3:34])=[C:20]([CH3:35])[N:19]=1>CN(C)C=O>[ClH:17].[CH3:34][C:21]1[C:22]([N:24]2[CH2:33][CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:25]2)=[N:23][C:18]([NH:9][CH2:1][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[N:19][C:20]=1[CH3:35]

Komponenten

5

Edukt 3

HCID 1001PhenethylamineHCID 8471TriethylamineHCID 183157432-Chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

Produkt 1

HCID 183156255,6-Dimethyl-2-phenylethylamino4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochlorideAusbeute 84,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

After phenethylamine(0.34 ml, 2.7 mmol) and triethylamine(0.38 ml, 2.7 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl) pyrimidine(0.5 g, 1.8 mmol) in dimethylformamide, 600 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.

Quellen und Nachweise

ORD-Eintrag
ord-4f6c1bfa05604cd8be7253988369dde6
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352993B1

Notizen zur Reaktion

Wird geladen…