HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthalenemethanamine → 5,6-Dimethyl-2-(1-naphthylmethyl)amino-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthalenemethanamine | HCID 8355 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315743 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Dimethyl-2-(1-naphthylmethyl)amino-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride | HCID 18315781 | 87.7% |
Reaction Steps
After 1-naphthylmethylamine(0.40 ml, 2.7 mmol) and triethylamine (0.38 ml, 2.7 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(0.5 g, 1.8 mmol) in dimethylformamide, 680 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06352993B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-543e57fb366240cf863613b557f49a20 |
| Source note | uspto-grants-2002_03 |