Cyclohexylamine → 5,6-Dimethyl-2-(cyclohexylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride

HRID 275913Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 275913
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Cl:15][C:16]1[N:21]=[C:20]([N:22]2[CH2:31][CH2:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23]2)[C:19]([CH3:32])=[C:18]([CH3:33])[N:17]=1>CN(C)C=O>[ClH:15].[CH3:32][C:19]1[C:20]([N:22]2[CH2:31][CH2:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23]2)=[N:21][C:16]([NH:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:17][C:18]=1[CH3:33]

Komponenten

5

Edukt 3

HCID 7965CyclohexylamineHCID 8471TriethylamineHCID 183157432-Chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

Produkt 1

HCID 183156185,6-Dimethyl-2-(cyclohexylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochlorideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

After cyclohexylamine(0.31 ml, 2.7 mmol) and triethylamine(0.38 ml, 2.7 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl) pyrimidine(0.5 g, 1.8 mmol) in dimethylformamide, 340 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.

Quellen und Nachweise

ORD-Eintrag
ord-367dc0e512ca4f37973ab1df8034f72f
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352993B1

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