HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5,6-Dimethyl-2-(3-trifluoromethylphenylmethyl)amino-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(Trifluoromethyl)benzylamine | HCID 75962 | — |
| Reactant | 5,6-Dimethyl-2-chloro4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 11185318 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Dimethyl-2-(3-trifluoromethylphenylmethyl)amino-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride | HCID 18315783 | 78.2% |
Reaction Steps
After 3-trifluoromethylbenzylamine(0.30 ml, 2.61 mmol) and triethylamine(0.36 ml, 2.59 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(0.5 g, 1.74 mmol) in dimethylformamide, 630 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06352993B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-c6e4741c539243bcb01ccc232985ee5b |
| Source note | uspto-grants-2002_03 |