HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18315665, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 5,6-Dimethyl-2-chloro4-(6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315631 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18315665 | HCID 18315665 | 2,260% |
Reaction Steps
After 4-fluoroaniline(0.72 ml, 7.5 mmol) and triethylamine(1.0 ml, 7.3 mmol) were added to a solution of 5,6-dimethyl-2-chloro4-(6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(1.6 g, 5.0 mmol) in dimethylformamide(10 ml), 1.26 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06352993B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-51b3db60ab8548198674e0a3c1bb32ed |
| Source note | uspto-grants-2002_03 |