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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 275941Generated: October 26, 2026

Triethylamine → HCID 18315665, compound

https://huagongshe.com/reaction/275941

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
Reactant4-FluoroanilineHCID 9731—
Reactant5,6-Dimethyl-2-chloro4-(6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidineHCID 18315631—
SolventDimethylformamideHCID 6228—
ProductHCID 18315665HCID 183156652,260%

Reaction Steps

After 4-fluoroaniline(0.72 ml, 7.5 mmol) and triethylamine(1.0 ml, 7.3 mmol) were added to a solution of 5,6-dimethyl-2-chloro4-(6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(1.6 g, 5.0 mmol) in dimethylformamide(10 ml), 1.26 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 25.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06352993B1
Source datasetuspto-grants-2002_03
ORD IDord-51b3db60ab8548198674e0a3c1bb32ed
Source noteuspto-grants-2002_03