HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5,6-Dimethyl-2-chloro-4-(7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Dichloro-5,6-dimethylpyrimidine | HCID 241553 | — |
| Reactant | 7-Methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline | HCID 15940011 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Dimethyl-2-chloro-4-(7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315818 | 70.3% |
Reaction Steps
After 1-methyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline (0.9 g, 5.1 mmol) and triethylamine(0.7 ml, 5.1 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimidine (0.8 g, 4.64 mmol) in dimethylformamide, 1.0 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35. (Yield: 70.3%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06352993B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-77bdd955311540bd908dc59913ce9e7b |
| Source note | uspto-grants-2002_03 |