Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 5,6-Dimethyl-2-chloro-4-(5-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,4-Dichloro-5,6-dimethylpyrimidine | HCID 241553 | — |
| 반응물 | 1-Methyl-5-methoxy-1,2,3,4-tetrahydro-isoquinoline | HCID 18315646 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5,6-Dimethyl-2-chloro-4-(5-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | HCID 18315830 | 70.3% |
반응 단계
After 1-methyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline(0.9 g, 5.1 mmol) and triethylamine(0.7 ml, 5.1 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimidine(0.8 g, 4.64 mmol) in dimethylformamide, 1.0 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35. (Yield: 70.3%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06352993B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-0543e04e7ee04fb8af785085f92c62f4 |
| 출처 메모 | uspto-grants-2002_03 |