Boron tribromide → HCID 18315822, compound

HRID 275954Notes

Reaction equation

[CH3:1][C:2]1[C:3]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]2[CH2:27][O:28]C)=[N:4][C:5]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[N:6][C:7]=1[CH3:8].B(Br)(Br)Br>>[CH3:1][C:2]1[C:3]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]2[CH2:27][OH:28])=[N:4][C:5]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[N:6][C:7]=1[CH3:8]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 18315663HCID 18315663, compound

Product 1

HCID 18315822HCID 18315822, compoundYield 39.6%

Procedure

The same procedures as in Example 32 were repeated using 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methoxymethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-pyrimidine(0.4 g, 1.0 mmol) and boron tribromide(1M-dichloromethane solution, 4.0 ml, 4.0 mmol) to afford 150 mg of the titled compound.

Sources & evidence

ORD record: ord-da6bebad8b0545d48a3370b60e61724d
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06352993B1

Reaction notes

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