Triethylamine → 5,6Dimethyl-2-(4-fluorophenylamino)-4-{1-methyl-6-(1-piperidineacetoxy)-1,2,3,4-tetrahydroisoquinolin-2-yl}pyrimidine dihydrochloride

Participants

Reaction Steps

The same procudures as in Example 167 were repeated using 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(50 mg, 0.132 mmol), 1-hydroxybenzotriazole(26.8 mg, 0.198 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(32.9 mg, 0.171 mmol), 1-piperidineacetic acid hydrochloride (28.5 mg, 0.158 mmol), and triethylamine(46 μl, 0.330 mmol) to afford the titled compound.

Provenance & Evidence