Chloromethyl Methyl Ether → HCID 18315823, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-Fluorophenylamino)-6-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquino-line-2-yl)pyrimidine (0.9 g, 2.58 mmol) was added to chloromethyl methyl ether (3 ml) in a sealed tube. The mixture was stirred at 80° C. for 1 day. After cooling to room temperature, ethyl ether was added to mixture. Resulting solid was removed by filtration. Filtrate was washed with aqueous 2N NaOH solution, dried over sodium sulfate, and concentrated under reduced pressure. Crude product was purified with a silica gel column chromatography (eluent: ethyl acttate:hexane=1:3). Purified compound was treated with HCl solution in ethyl ether. Precipitated solid was isolated by filtration, washed with ethyl ether, and dried in vacuum. It gave 0.6 mg of the titled compound.

Provenance & Evidence